2025年

• Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases.
  Fujitani M.*, Tarif AMM, Otani Y. Neural Regeneration Research 20(1):p 193-194.
  

2024年

• 神経筋接合部異常とインスリン様成長因子による治療法開発の可能性
  藤谷昌司,  石原弘基, Tarif Abu, Md Mamun,  大谷嘉典
  島根医学 44(1) 1-8 2024年6月

2023年

2022年

• Pathophysiological roles of abnormal axon initial segments in neurodevelopmental disorders.
  Fujitani M*, Otani Y, Miyajima H
  Cells 10,2110
  

2020年

2019年

• New nociceptive circuits to the hypothalamic perifornical areafrom the spinal cord and spinal trigeminal nucleus via the parabrachial nucleus
  Asano H(#), Arima Y(#), Yokota S, Fujitani M*   (#: contributed equally)
  Biochemical and Biophysical Research Communications May 14; 512(4): 705-711.

• Lateral parabrachial neurons innervate orexin neurons projecting to brainstem arousal areas in the rat.
  Arima Y, Yokota S, Fujitani M*
  Scientific Reports  9, Article number: 2830 

2018年

• Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.
  Abe Y, Honsho M, Itoh R, Kawaguchi R, Fujitani M, Fujiwara K, Hirokane M, Matsuzaki T, Nakayama K, Ohgi R, Marutani T, Nakayama KI, Yamashita T, Fujiki Y
  Life science alliance 1(6) e201800062 

2017年

• A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling.
  Fujitani M*, Zhang S, Fujiki R, Fujihara Y, Yamashita T*
  Molecular Psychiatry 22(3) 364-374 

• Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis.
  Fujitani M*, Sato R, Yamashita T*
  Scientific reports 7(1) 12007 

• The RNA binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain.
  Kanemitsu Y, Fujitani M*, Fujita Y, Zhang S, Su Y, Kawahara Y, Yamashita T*
  Scientific reports 7(1) 1155 

2016年

• NME2 associates with PTPσ to transduce signals from chondroitin sulfate proteoglycans.
  Hamasaki H, Fujitani M*, Yamashita T*
  Biochemical and biophysical research communications 471(4) 522-527 

2014年

• The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex.
  Zhang S, Kanemitsu Y, Fujitani M*, Yamashita T*
  Scientific reports 4 5984 2014年8月

2013年

• Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.
  Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M  Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD
  Cell stem cell 13(5) 564-576 

• A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons
  Fujiki R, Sato A, Fujitani M*, Yamashita T*
  Cell Death & Disease 4(6) e677 – e677 

• Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis.
  Fujiki R, Sato A, Hata K, Tashiro F, Yasuhara N, Miyazaki J, Yoneda Y, Fujitani M*, Yamashita T
  Biochemical and biophysical research communications 430(2) 604-609 

2010年

• TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.
  Fujitani M, Cancino GI, Dugani CB, Weaver IC, Gauthier-Fisher A, Paquin A, Mak TW, Wojtowicz MJ, Miller FD, Kaplan DR
  Current biology : CB 20(22) 2058-2065 

2009年

• p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.
  Dugani CB, Paquin A, Fujitani M, Kaplan DR, Miller FD
  The Journal of neuroscience  29(20) 6710-6721 

2008年

• TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
  Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M  Rufini A, Cheung CC, Khan F, Itie-Youten A, Wakeham A, Tsao MS, Iovanna JL, Squire J, Jurisica I, Kaplan D, Melino G, Jurisicova A, Mak TW
  Genes & development 22(19) 2677-2691 

• p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer’s disease.
  Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M  Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR
  Neuron 59(5) 708-721 

• Rap1 is involved in the signal transduction of myelin-associated glycoprotein.
  Taniguchi J¹, Fujitani M¹, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T
  Cell death and differentiation 15(2) 408-419 

2007年

• Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy.
  Yasuda H, Sanada M, Kitada K, Terashima T, Kim H, Sakaue Y, Fujitani M, Kawai H, Maeda K, Kashiwagi A
  Diabetes research and clinical practice 77 178-183 

2006年

• Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury.
  Hiraga A, Kuwabara S, Doya H, Kanai K, Fujitani M, Taniguchi J, Arai K, Mori M, Hattori T, Yamashita T
  Journal of the peripheral nervous system  11(3) 217-224 

• Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.
  Nishio Y, Koda M, Kitajo K, Seto M, Hata K, Taniguchi J, Moriya H, Fujitani M, Kubo T, Yamashita T
  Experimental neurology 200 392-397 

• Induction of repulsive guidance molecule in neurons following sciatic nerve injury.
  Doya H, Ito T, Hata K, Fujitani M, Ohtori S, Saito-Watanabe T, Moriya H, Takahashi K, Kubo T, Yamashita T
  Journal of chemical neuroanatomy 32 74-77 

• Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism.
  Mimura F, Yamagishi S, Arimura N, Fujitani M, Kubo T, Kaibuchi K, Yamashita T
  The Journal of biological chemistry 281(23) 15970-15979 

• RGMa inhibition promotes axonal growth and recovery after spinal cord injury.
  Hata K, Fujitani M, Yasuda Y, Doya H, Saito T, Yamagishi S, Mueller BK, Yamashita T
  The Journal of cell biology 173(1) 47-58 

2005年

• Molecular mechanism that inhibits axon regeneration.
  Yamashita T, Fujitani M, Hata K, Mimura F
  Seikagaku. The Journal of Japanese Biochemical Society 77 1475-1480 

• Multiple signals regulate axon regeneration through the Nogo receptor complex.
  Yamashita T, Fujitani M, Yamagishi S, Hata K, Mimura F
  Molecular neurobiology 32 105-111 

• c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity.
  Doya H, Ohtori S, Fujitani M, Saito T, Hata K, Ino H, Takahashi K, Moriya H, Yamashita T
  Biochemical and biophysical research communications 335(1) 132-138 

• Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction.
  Fujitani M, Kawai H, Proia RL, Kashiwagi A, Yasuda H, Yamashita T
  Journal of neurochemistry 94(1) 15-21 

• Wallerian degeneration involves Rho/Rho-kinase signaling.
  Yamagishi S, Fujitani M, Hata K, Kitajo K, Mimura F, Abe H, Yamashita T
  The Journal of biological chemistry 280(21) 20384-20388 

• Inhibition of axon regeneration by myelin inhibitors.
  Yamashita T, Fujitani M, Hata K, Yamagishi S
  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 50 403-409 

• Diverse functions of the p75 neurotrophin receptor.
  Yamashita T, Fujitani M, Hata K, Mimura F, Yamagishi S
  Anatomical science international 80 37-41 

• Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts.
  Fujitani M, Honda A, Hata K, Yamagishi S, Tohyama M, Yamashita T
  Biochemical and biophysical research communications 327(1) 150-154 

2004年

• P311 accelerates nerve regeneration of the axotomized facial nerve.
  Fujitani M, Yamagishi S, Che YH, Hata K, Kubo T, Ino H, Tohyama M, Yamashita T
  Journal of neurochemistry 91(3) 737-744 

• Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G.
  Hasegawa Y¹,Fujitani M¹, Hata K, Tohyama M, Yamagishi S, Yamashita T

  The Journal of neuroscience 24 6826-6832 

• Activation of Rho in the injured axons following spinal cord injury.
  Madura T, Yamashita T, Kubo T, Fujitani M, Hosokawa K, Tohyama M
  EMBO reports 5 412-417 

• p75 neurotrophin receptor signaling in the nervous system.
  Hasegawa Y, Yamagishi S, Fujitani M, Yamashita T
  Biotechnology annual review 10 123-149 

2002年

• SUMO-1 co-localized with mutant atrophin-1 with expanded polyglutamines accelerates intranuclear aggregation and cell death.
  Terashima T, Kawai H, Fujitani M, Maeda K, Yasuda H
  Neuroreport 13(17) 2359-2364 

業績等へのリンク

横田グループは、呼吸や睡眠、摂食といった自律機能を制御する中枢内神経回路を、形態学的および機能的に明らかにする研究を行っている。

業績等へのリンク

業績等へのリンク